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Seattle Structural Genomics Center for Infectious Disease

NafoA.18809.a: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR)

Target Characteristics

from organism: Naegleria fowleri ATCC 30863
most recent status: purified
center reference id: NafoA.18809.a
is community request: True
associated disease:
NIH risk group: 2
is select agent: False
NIH priority
pathogens category:
IIB

Ordering Clones & Proteins

If there are materials available for this target, they will be listed below. Materials can be ordered from SSGCID using the button in the "order material" column. Clicking the button will add the material to a virtual cart. You may order multiple materials at a time at no cost to you, as this contract is funded by NIAID. When you are ready to place your order, click the "Place Order" link which will appear in the top right corner of the page after you place your first item in your cart.

Clones*

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
NafoA.18809.a.B2.GE41829 C-term sim to SmHMGR cat domain 55 483 GE41829
NafoA.18809.a.B3.GE41830 XtalPred shorter C-term domain 98 483 GE41830
* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers. Clones may contain a tag, such as N-term 6xHis. Get sequence information using the button in the "info" column.

Proteins

CENTER
REFERENCE ID
DOMAIN/REGION
DESCRIPTION
INFO AA
START
AA
STOP
ORDER
MATERIAL
NafoA.18809.a.B2.PW38407 C-term sim to SmHMGR cat domain 55 483

External Resources

Resource Reference ID
EuPathDB: AmoebaDB:NF0036310

Sequences

These sequences are the native gene sequence; sequences of constructs derived from these sequences may differ due to codon optimization or other protocols. To find the specific sequence of any material you may have ordered, click on the "more" button next to the name of that material.
AA Sequence
MSTNRLFRVL ILVFIHGSIE KIQVVTEIGN NVCAVRIEET SEEAIQRELE QEKEEHEEAK RKEQERYRQL SDGAIIDLLE NGKLALYNLE DKLGDKKRAV KIRRMFLAAK INPQDETILD TLPYANDLNY DHVFGACCES VVGYVPLPVG IVGPIIIDGK PYHIPMATVE GCLVASTHRG CKALSSSLEG GVNSVILSDG MTRGPVVQFA NAKRCYELKQ YIENPENFQT ICRVFNSDSR FARLLEIKVG IAGRKAFLRF KCRTGDAMGM NMISKATQKA LKFLKHELFP DMDILSLSGN YCTDKKPSAM NWIEGRGKSV VVDATIPADV VKSVLKTTVD EIVSLNVSKN LIGSAMAGSI GGFNAHAANI VTAIFLATGQ DAAQNVESSN CMTIMEKTPE GHLYVSVTMP SIEVGTVGGG THLDAQKTCL KIMGVAGANM ENPGQNAQTL AKCVASTVMA GELSLMAALA ADHLVSAHIA HNRKK

NT Sequence
atgtcaacaa atcgtctgtt ccgtgttctt attcttgtgt tcatacatgg cagcattgaa aaaattcaag tagtgactga gattggtaat aatgtgtgtg ctgttagaat cgaagaaacc tcagaagaag cgattcaacg agaattggaa caagagaagg aggaacacga agaagcaaag agaaaggaac aagaaagata tagacaatta tctgatggag ctatcattga tttattagag aatggaaagc tcgctctcta caatctcgaa gataagcttg gagataagaa gcgtgctgtt aaaatccgta gaatgttcct tgcagcaaaa atcaatccac aagatgaaac aatactagat acacttcctt atgctaatga tttaaattat gatcatgtgt ttggagcttg ttgtgaaagt gtggttggtt atgttccttt acctgttggt atcgttggtc caataataat tgatggtaag ccatatcata ttccaatggc tactgttgaa ggctgtcttg ttgccagtac tcatagaggt tgcaaggctc tttcgagctc attagaagga ggagtgaaca gtgtcatcct ctcagacgga atgactagag gtccagtcgt tcaattcgct aatgcaaaga gatgttatga actcaaacaa tacattgaga atccagaaaa tttccaaacc atttgccgag ttttcaacag tgattctcgt tttgctagat tattagaaat taaggtcggt attgctggaa gaaaggcttt cttgagattt aaatgtagga cgggtgatgc catgggtatg aatatgatct ctaaagccac acaaaaagca ttgaaatttt tgaaacacga actcttccct gatatggata ttttaagctt gagtggtaac tactgcacag acaaaaagcc atcagcaatg aactggattg aaggaagagg aaaatctgtg gttgttgatg ctactattcc agcagatgtt gtgaaatcag ttctcaagac tactgtagac gaaattgtga gtctcaatgt gagcaagaac ttgattggaa gcgctatggc tggctctatt ggtggtttca acgctcatgc cgctaacatt gtgaccgcca tctttttagc aactggtcaa gacgctgctc aaaacgtcga aagttcgaat tgtatgacaa taatggaaaa gactccagaa ggacatttat atgtaagcgt gactatgcca tccatcgaag ttggaactgt tggtggtggt actcacttgg atgctcaaaa gacctgtctc aagattatgg gagttgcagg cgcaaatatg gaaaacccag gtcaaaatgc tcaaacgctt gccaagtgcg tggccagtac cgtcatggca ggtgaacttt ctttaatggc tgctcttgct gctgatcatt tagtttctgc ccacattgct cacaacagaa agaagtaa

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