NIAID Emerging and Re-emerging Infectious Diseases NIAID Bioinformatics Resource Centers NIAID Structural Genomic Centers Center for Structural Genomics of Infectious Disease

Target Status for Leishmania Targets

SSGCID ID [Center ID]	Family ID	Annotation	Target Approved	Selected	Cloned	Expressed	Soluble	Purified	Crystal- lized	Diff- raction Data	HSQC	NMR Assigned	In PDB	Work Stopped	Expression Clones* Available	Protein Available	Most Recent Activity
LebrA.18809.a	18809	3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	True	True	False	False	False	False	False	False	False	False	False	False	0	0	12/15/2016
LedoB.18809.a	18809	3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	True	True	True	True	False	False	False	False	False	False	False	False	1	0	2/13/2017
LemaA.18809.a	18809	3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	True	True	True	True	False	False	False	False	False	False	False	False	1	0	1/5/2017
LemaA.01610.a	01610	6-phosphogluconate dehydrogenase, decarboxylating	True	True	False	False	False	False	False	False	False	False	False	False	0	0	1/24/2012
LeinA.17829.a	17829	A2 protein	True	True	False	False	False	False	False	False	False	False	False	False	0	0	2/27/2013
LemaA.01291.a	01291	adenylate kinase, putative	True	True	False	False	False	False	False	False	False	False	False	False	0	0	2/2/2012
LemaA.01291.b	01291	adenylate kinase, putative	True	True	True	True	True	False	False	False	False	False	False	False	1	0	5/8/2012
LemaA.00628.a	00628	adenylate kinase, putative	True	True	True	True	True	True	False	False	False	False	False	False	1	1	8/24/2012
LebrA.00424.a	00424	AGC family serine/threonine kinase, putative	True	True	True	True	False	False	False	False	False	False	False	False	1	0	11/11/2016
LedoB.00424.a	00424	AGC family serine/threonine protein kinase (STPK), putative	True	True	False	False	False	False	False	False	False	False	False	False	0	0	1/11/2017
LetaA.18889.a	18889	Alanyl-tRNA synthetase, putative	True	False	False	False	False	False	False	False	False	False	False	False	0	0	12/18/2018
LemeA.18889.b	18889	alanyl-tRNA synthetase, putative	True	False	False	False	False	False	False	False	False	False	False	False	0	0	4/16/2018
LebrA.18889.a	18889	alanyl-tRNA synthetase, putative	True	True	False	False	False	False	False	False	False	False	False	False	0	0	9/5/2018
LedoB.18889.a	18889	alanyl-tRNA synthetase, putative	True	True	True	True	True	False	False	False	False	False	False	False	1	0	10/17/2018
LemaA.18889.a	18889	alanyl-tRNA synthetase, putative	True	True	True	True	True	False	False	False	False	False	False	False	0	0	1/9/2019
LeinA.19156.a	19156	AMPK; Uncharacterized protein; alpha-subunit-like	True	True	True	True	False	False	False	False	False	False	False	False	1	0	6/10/2015
LetaA.18295.a	18295	Arginyl-tRNA synthetase, putative	True	False	False	False	False	False	False	False	False	False	False	False	0	0	12/18/2018
LemeA.18295.a	18295	arginyl-tRNA synthetase, putative	True	False	False	False	False	False	False	False	False	False	False	False	0	0	4/16/2018
LedoB.18295.a	18295	arginyl-tRNA synthetase, putative	True	True	False	False	False	False	False	False	False	False	False	False	0	0	7/24/2018
LebrA.00164.a	00164	arginyl-tRNA synthetase, putative	True	True	True	True	True	False	False	False	False	False	False	False	1	0	7/10/2018
1 of 24 Total Records: 466

* SSGCID clones represent un-induced expression constructs which have been verified by sequencing from vector primers.